Moogie
10-07-2003, 06:35 PM
Here's a bit of an update from <a href="http://distributedfolding.net/news.html"><b>Howard.</b></a> Keep your eye on this spot, as there's more to come.<br><br><b><i>10/07/2003</b> <br><br>- We are now on the last protein of our folding 'mini-experiment', protein L with a 14-residue floppy tail removed. Both this protein and protein G (two proteins back) have been folded essentially to completion (well under 3A RMSD) and so the folding pathways we have obtained can be compared to experimental observations of folding pathways, as well as simulated unfolding pathways, to learn a bit more about how proteins fold. As we analyze the data over the next few months we will post results here. For the next protein, we will switch back to an energy-only scoring function (not RMSD-based), so that we will be doing true blind prediction. Thus expect higher RMSDs to native than we have been seeing recently. Our hope, of course, is that we are still able to completely fold proteins using the current approach without using the explicit knowledge of the native structure that we have been using for the last few proteins.</i><br><br><br>