Digital Parasite
08-28-2007, 02:44 PM
Check out David Baker's log for the latest news:
http://boinc.bakerlab.org/rosetta/forum_thread.php?id=1177
The new Rosetta@Home Game:
I've been working with several others in the lab on an "interactive Rosetta" project. The vision is that one day, you'll be able to interact with Rosetta as it runs, both (1) to help it produce better results and (2) to learn about what it's doing.
We're not there yet, but we have an early prototype for #2, the educational side. This is a simple "game" you can play in your web browser (using Java) to find the missing side chain for a designed protein that might be used to fight cancer. In this case, there's a small number of choices and the right answer should be obvious. However, it illustrates one of the basic steps that Rosetta performs thousands of times every time it designs a protein.
More "levels" for the game will be coming in the future. Also we're already planning to change the interface on the Java applet and to add a "score board" so you can compete against others, but if you try it out and have other comments or ideas to share, please post them here.
Here's the link: http://boinc.bakerlab.org/rosetta/rah_misc/king_rotamer_game/
Some exciting new results:
The results of the last few days of computations of Rosetta@home on your computers have been pretty amazing! In collaboration with a group at the NIH, we experimented with adding a very small amount of information about protein structures from nuclear magnetic resonance experiments to the rosetta structure prediction process. this information is fairly easily obtainable, and doesn't seem like it would have much effect, but the results show quite contrary--the models produced are extremely accurate! this has the potential to revolutionize how scientists determine protein 3D structures using NMR data. We would never have been able to test the idea, which came up in a phone conversation several months ago, without all of your contributions.
Today I spoke at the AidsVaccine07 meeting about our work on designing vaccines. Scientists who have been working on this very challenging problem for many years are I think excited about our approach as it is something that hasn't been tried before and makes sense conceptually. While we are still far from a vaccine, our initial results with collaborators at the NIH are promising. I spoke to a reporter from the Wall Street Journal after my talk, and I think she is interested in writing an article on rosetta@home and HIV vaccine design.
Rosetta@Home work is being published in the prestigious Nature journal:
Congratulations! Your collective results on structure prediction, protein structure refinement, and solving the X-ray crystallographic phase problem with rosetta@home were just yesterday accepted for publication as a research article in the journal Nature which many of you can find at your local newstands (I'll post here when the issue appears in print). As those of you familar with scientific publishing are certainly aware, Nature is probably the most widely read journal in the natural sciences, and only one or two research articles are published in any issue (almost all are shorter letters), so your work will reach a very broad audience and have exceptionally wide impact.
http://boinc.bakerlab.org/rosetta/forum_thread.php?id=1177
The new Rosetta@Home Game:
I've been working with several others in the lab on an "interactive Rosetta" project. The vision is that one day, you'll be able to interact with Rosetta as it runs, both (1) to help it produce better results and (2) to learn about what it's doing.
We're not there yet, but we have an early prototype for #2, the educational side. This is a simple "game" you can play in your web browser (using Java) to find the missing side chain for a designed protein that might be used to fight cancer. In this case, there's a small number of choices and the right answer should be obvious. However, it illustrates one of the basic steps that Rosetta performs thousands of times every time it designs a protein.
More "levels" for the game will be coming in the future. Also we're already planning to change the interface on the Java applet and to add a "score board" so you can compete against others, but if you try it out and have other comments or ideas to share, please post them here.
Here's the link: http://boinc.bakerlab.org/rosetta/rah_misc/king_rotamer_game/
Some exciting new results:
The results of the last few days of computations of Rosetta@home on your computers have been pretty amazing! In collaboration with a group at the NIH, we experimented with adding a very small amount of information about protein structures from nuclear magnetic resonance experiments to the rosetta structure prediction process. this information is fairly easily obtainable, and doesn't seem like it would have much effect, but the results show quite contrary--the models produced are extremely accurate! this has the potential to revolutionize how scientists determine protein 3D structures using NMR data. We would never have been able to test the idea, which came up in a phone conversation several months ago, without all of your contributions.
Today I spoke at the AidsVaccine07 meeting about our work on designing vaccines. Scientists who have been working on this very challenging problem for many years are I think excited about our approach as it is something that hasn't been tried before and makes sense conceptually. While we are still far from a vaccine, our initial results with collaborators at the NIH are promising. I spoke to a reporter from the Wall Street Journal after my talk, and I think she is interested in writing an article on rosetta@home and HIV vaccine design.
Rosetta@Home work is being published in the prestigious Nature journal:
Congratulations! Your collective results on structure prediction, protein structure refinement, and solving the X-ray crystallographic phase problem with rosetta@home were just yesterday accepted for publication as a research article in the journal Nature which many of you can find at your local newstands (I'll post here when the issue appears in print). As those of you familar with scientific publishing are certainly aware, Nature is probably the most widely read journal in the natural sciences, and only one or two research articles are published in any issue (almost all are shorter letters), so your work will reach a very broad audience and have exceptionally wide impact.