Which OS?
Win 9x/ME? If so, then that's possible. Try running something like memtest86 or whatever.
If it's NT/2K/XP/Linux, then it's highly unlikely that DF would be to blame. With those OS'es, memory is split up differently so that it's much less likely that a single process brings down the entire machine. I suppose it might be possible, but it would still be extremely unlikely.
Which chipset? Are you using AGP at all?