Hi BOINC volunteers,

We are a fairly new project that has been running for about 3 years or so now. We are an academic group located in Université de Sherbrooke (Québec, Canada) and NRG stands for Najmanovich Research Group. Our project is already listed on BOINCstats: http://boincstats.com/en/stats/126/user/list/.

The address of the project is the following: http://boinc.med.usherbrooke.ca/nrg

As some of you may already know, we are mostly interested into drug design. We have been developing FlexAID, a method that allows to predict if a molecule may act/bind on a particular target. More info on our method can be found here: http://bcb.med.usherbrooke.ca/boinc.php.

We are currently investigating if our method can distinguish between true binders and non-binders. We are doing so for a lot of targets mentioned below[*]. We have nearly a million of tasks to execute and NRG needs your help!

We have had a few issues with FlexAID regarding Computation Errors in the past. However, those were all resolved through the many years of development.

Our method will soon be published in a scientific journal, and we wouldn't be here today if you, BOINC users, have not been there. We are very grateful and thanks a lot for your support.

Francis Gaudreault
Ph.D student & BOINC Administrator
[*] ACE, angiotensin-converting enzyme; AChE, acetylcholinesterase; ADA, adenosine deaminase; ALR2, aldose reductase; AmpC, AmpC beta-lactamase; AR, androgen receptor; CDK2, cyclin- dependent kinase 2; COMT, catechol O-methyltransferase; COX-1, cy- clooxygenase-1; COX-2, cyclooxygenase-2; DHFR, dihydrofolate reductase; EGFr, epidermal growth factor receptor; ER, estrogen receptor; FGFr1, fibroblast growth factor receptor kinase; FXa, factor Xa; GART, glycinamide ribonucleotide transformylase; GPB, glycogen phosphorylase beta; GR, glucocorticoid receptor; HIVPR, HIV protease; HIVRT, HIV reverse transcriptase; HMGR, hydroxymethylglutaryl-CoA reductase; HSP90, hu- man heat shock protein 90; InhA, enoyl ACP reductase; MR, mineralo- corticoid receptor; NA, neuraminidase; P38 MAP, P38 mitogen activated protein; PARP, poly(ADP-ribose) polymerase; PDE5, phosphodiesterase 5; PDGFrb, platelet derived growth factor receptor kinase; PNP, purine nucleoside phosphorylase; PPARg, peroxisome proliferator activated receptor γ; PR, progesterone receptor; RXRa, retinoic X receptor R; SAHH, S-adenosyl-homocysteine hydrolase; SRC, tyrosine kinase SRC; TK, thymidine kinase; VEGFr2, vascular endothelial growth factor receptor; ATP, adenosine-5′-triphosphate; beta-GAR, beta-glycinamide ribonucleotide; NAD(P)-(H), nicotinamide adenine dinucleotide (phosphate)-(reduced); PLP , pyridoxal-5′-phosphate.