I run my ATIs on old single or dual core machines. If I try to run a CPU project on them at the same time I actually get less credit. So on those machines it's GPU projects only. My Nvidias are all running on quads and CPU projects don't seem to affect the output.
The HD5990 should be awesome but unless you run it on an I7 you may spend a lot of time waiting for work. Milkyway still limits you to only 6 WUs per CPU core.